English 
Dutch 
Chinese 
SIGNATURE
Advanced Wellness Patch
Signature is the all-round wellness patch and the essence of the Mepho collection. Designed for people who experience tension, fatigue, imbalance, or reduced vitality in everyday life.
21 patches
€ 39,75
- Free shipping: NL €50+ · EU €70+ · UK £70+
- Delivery: 1–4 business days
Non-invasive · Additive-free · SGS-tested
Product information
Signature is chosen when support is needed as part of everyday life, not just in response to a single moment. It is designed for people who experience tension, fatigue, imbalance, or reduced vitality on a regular basis and are looking for steady, repeatable support rather than quick fixes.
Signature is based on the Acu-Resonance Method™. A method inspired by acupuncture that works with your body’s natural warmth. It supports your body’s natural balance and vitality and fits effortlessly into your daily routine.
Everyone experiences Signature differently. Some people notice subtle changes early on, while for others the effect builds gradually with consistent use. The patch itself is usually not felt. Signature works quietly in the background while you go about your day.
Signature is designed for regular use, during the day or overnight. It can also be applied locally to help ease tension or pain when needed.
Non-invasive · Additive-free · SGS-tested · Suitable for daily use
A different approach to wearable support
Signature uses the Acu-Resonance Method™. This Method has been developed by Mepho as a unique approach to everyday wellness. Each patch contains a specially developed layer that is activated by the body's natural warmth. When placed on specific points on the body, it provides subtle, non-invasive support.
Instead of relying on active ingredients or external stimulation, the method works with the body's own natural warmth. The interaction between patch and body is gentle and continuous, supporting the body without interfering with its natural processes.
The Acu-Resonance Method™ is inspired by traditional acupuncture, where point-based treatment is performed with needles. Mepho has built on this principle and now offers the same point-based approach through a patch you can simply wear throughout your day. Without needles and without additives.
The method is designed for both regular and situational use. Without additives and without overstimulation, it fits effortlessly into everyday life.
Each product in the Mepho collection applies this method in its own way. Signature uses it to provide all-round support for broad, everyday use.
Signature applies the Acu-Resonance Method™ through three carefully selected points on the body, for balanced, everyday support.
Once applied to the skin, the patches are activated by the body's natural warmth. The special layer inside each patch responds to this warmth and interacts with the body's own natural processes. The stimulation of these points continues for as long as you wear the patch, naturally supporting balance and vitality.
Signature is applied to three acupoint-inspired locations drawn from traditional acupuncture principles. These points are traditionally associated with different aspects of balance and vitality and are selected to work together as a system:
GV14 (Da Zhui)
Located at the base of the neck, this acupoint is traditionally associated with overall balance and the regulation of energy flow.
ST36 (Zu San Li)
Located below the knee, this acupoint is commonly linked to vitality, resilience, and sustained energy.
CV6 (Qi Hai)
Located on the lower abdomen, this acupoint is traditionally connected to core energy and physical stability.
Rather than focusing on a single point or function, Signature applies combined stimulation across these three acupoints. When stimulated together, they create a synergistic effect, supporting energy and vitality, helping the body maintain its natural balance, and building resilience against stress and fatigue.
The interaction is subtle and does not rely on noticeable sensation. The presence of the patch is rarely noticed while wearing it. Signature works quietly in the background, allowing the body's own processes to remain in the lead.
For exact placement and step-by-step guidance, see How to Apply.
Applying Signature is simple. Follow the steps below and use the diagram for visual guidance.
Step 1 | Prepare the skin
Clean and dry the skin before application.
Step 2 | Apply to the three acupoints
Apply one patch to each acupoint shown in the diagram.
GV14 | Da Zhui
Location: Base of the neck
How to find it: Tilt your head slightly forward and feel for the bony bump at the base of the neck. Apply the patch just below this point, centered along the spine.
ST36 | Zu San Li
Location: Below the knee
How to find it: Sit down and place four fingers below the kneecap. Move slightly to the outside of the shinbone. At the level of your little finger, you’ll feel a small dip. This is ST36.
CV6 | Qi Hai
Location: Lower abdomen
How to find it: Place two finger widths below the navel, on the midline of the body. Apply the patch directly at this point.
Step 3 | Secure and wear
Press each patch gently to ensure good adhesion. Wear for up to 8–12 hours, during the day or overnight, as needed.
Step 4 | Remove
Remove and discard after single use.
Alternative use (pain relief)
For local discomfort, apply the patch directly to the area of tension or pain.
Notes
- For external use only.
- Discontinue use if skin irritation occurs.
- SGS-tested for skin compatibility.
- Signature is not a medication and does not replace professional medical care.
Yes. Signature is designed for regular, everyday use. It is non-invasive, additive-free, and SGS-tested for skin compatibility. Many people use it daily or several times a week as a consistent part of their routine.
Signature patches are typically worn for 8–12 hours. You can use them during the day or overnight, depending on what works best for you.
Yes. Signature is designed as a three-point system. Using all three patches together supports the method as intended and creates a balanced effect.
The effect of Signature is subtle. Some people notice gentle changes, while for others the effect builds gradually with consistent use. You will usually not feel the patch itself. Signature works quietly in the background while you go about your day.
Yes. Signature can be used while sleeping and during daily activities, including exercise, as long as the patches remain comfortable and stay securely in place.
Signature is SGS-tested skin compatibility and free from active ingredients and additives. If you have sensitive skin, start with a shorter wear time and check your skin after use. Discontinue use if irritation occurs.
Yes. In addition to its all-round use, you can also apply Signature to areas of tension or discomfort. Apply the patch directly to the area where you feel it.